
Medical Studies
Scientifically substantiated health claims
When you make conscious choices for an investment in your health, reliable information is of great importance. On this page you will find an extensive collection of scientific studies. Each study aims to systematically assess the effect of pressure, oxygen or hydrogen content in the air, with the aim of assessing its performance and safety. The applications of hydrogen intake are also still being investigated, with promising results so far.
We invite you to explore the scientific substantiation yourself, so that you can choose to invest in your Normocare room with confidence.
Are you looking for something specific?
Would you prefer a bit of explanation, or can we help you find references for a specific clinical picture or application? We are continuously studying the growing number of publications related to the conditions as applied in the Normocare room. Don’t hesitate, contact us today.


Hyperbaric versus normobaric conditions
Hyperbaric and normobaric therapy are both methods that use oxygen to promote healing and recovery, but there is an important difference in the applied pressure conditions. Hyperbaric therapy occurs at increased pressure, which allows more oxygen to be absorbed into the blood. Normobaric therapy in a Normocare chamber, on the other hand, takes place at very slightly elevated atmospheric pressure up to a maximum of 1.5 bar. In these conditions we accelerate the absorption of the gases in the chamber into the body, without the risks associated with hyperbaric conditions.
Normocare adds an extra dimension to this: hydrogen as a secret weapon, both in the air of the chamber and in the hydrogen water you drink there.
Although many studies have been conducted in hyperbaric conditions, the underlying biological effects – such as improved cell repair, inflammation inhibition and stimulation of growth and repair processes – are also relevant in normobaric applications, although possibly to a lesser extent or requiring application over a longer period of time. Normobaric therapy in a Normocare room, however, is pleasant and safe, so you can stay in the room for several hours and not even notice that you are being treated.
Disclaimer
The information on this website is for informational purposes only and should not be considered medical advice, diagnosis or treatment. Always consult with a qualified physician or medical specialist before making any decisions about your health or starting a new treatment protocol.
Although we refer to various scientific studies, these studies have been conducted independently and are not sponsored or influenced by our company. We cannot give any guarantees about effectiveness on an individual level. Use of the information on this website is at your own responsibility.
Scientific sources
General Health
- A General Overview on the Hyperbaric Oxygen Therapy: Applications, Mechanisms and Translational Opportunities – PMC
- Normobaric oxygen treatment for mild-to-moderate depression: a randomized, double-blind, proof-of-concept trial
- Autonomic and Cognitive Function Response to Normobaric Hyperoxia Exposure in Healthy Subjects. Preliminary Study
- Autonomic and Cognitive Function Response to Normobaric Hyperoxia Exposure in Healthy Subjects. Preliminary Study – PubMed
- The Neuroprotection Effect of Oxygen Therapy: A Systematic Review and Meta-analysis
- Allergies: Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells
- Antioxidant: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals – PubMed
- Anti-aging: Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells
- Anti-aging: (Lengthening telomeres, increases telomerase expression): Effects of Hydrogenized Water on Intracellular Biomarkers for Antioxidants, Glucose Uptake, Insulin Signaling and SIRT 1 and Telomerase
- Anti-inflammatory: Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation
- Burns: Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation
- Burns: Protective effects of hydrogen against severe burns
- Cholesterol: Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome—An Open Label Pilot Study
- Hay Fever: Changes in IL-4 and IL-13 expression in allergic-rhinitis treated with hydrogen-rich saline in guinea-pig model
- High blood glucose: Role of hydrogen gas in regulating of poly (ADP-ribose) polymerase-1 dependent cell death in rat Schwann cells
- Molecular hydrogen: a preventive and therapeutic medical gas for various diseases – PubMed
- Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine – PubMed
- Neuropathic pain: H2 Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain
- Pain (reduces heightened sensitivity to pain): Hydrogen-rich saline prevents remifentanil-induced hyperalgesia and inhibits MnSOD nitration via regulation of NR2B-containing NMDA receptor in rats
- Protects against Aspirin damage: Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats
- Protects against Tylenol damage: Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice
- Seasonal allergies: Hydrogen-rich saline attenuates eosinophil activation in a guinea pig model of allergic rhinitis via reducing oxidative stress
- Skin wrinkles: Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes
- Smoking: Attenuation of Cigarette Smoke-Induced Airway Mucus Production by Hydrogen-Rich Saline in Rats
- Smoking: Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury
- Supports immune system: The immunological effects of electrolyzed reduced water on the Echinostoma hortense infection in C57BL/6 mice
- Supports immune system: Protective effect of hydrogen-rich saline against radiation-induced immune dysfunction
- Wounds: Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model
Wound healing
- The initiation of oxidative stress and therapeutic strategies in wound healing
- Systematic review of the effects of topical oxygen therapy on wound healing
- Oxygen therapies and their effects on wound healing
- Enhanced healing and cost-effectiveness of low-pressure oxygen therapy in healing necrotic wounds: a feasibility study of technology transfer
- Hyperbaric oxygen therapy for wound healing and limb salvage: a systematic review
- Oxygen in acute and chronic wound healing
- Influence of oxygen on wound healing
- Cellular and molecular roles of reactive oxygen species in wound healing
- The Role of Hyperbaric Oxygen Therapy for the Treatment of Wounds
- Oxygen therapies and their effects on wound healing
- Wound repair and regeneration
Wound healing burn wounds
- Hyperbaric oxygen therapy for thermal burns
- Bactericidal effect of hyperbaric oxygen therapy in burn injuries
- Hyperbaric Oxygen Therapy for Burn Injuries: A Case Study and Review
- Hyperbaric and topical oxygen therapies in thermal burn wound healing: a review
- Effects of hyperbaric oxygen therapy on the healing of thermal burns and its relationship with ICAM-1: A case-control study
- The Effect of Hyperbaric Oxygen Treatment on the Healing of Burn Wounds in Nicotinized and Nonnicotinized Rats
- (PDF) Update on hyperbaric oxygen therapy in burn treatment
- Therapeutic Outcome of Burn Patients Treated With Hyperbaric Oxygen
- Mast Cells in Regeneration of the Skin in Burn Wound with Special Emphasis on Molecular Hydrogen Effect
- Molecular Hydrogen and Its Effect on Wound Healing and Tissue Regeneration
- Beneficial Effects of Hydrogen-Rich Saline on Early Burn-Wound Progression in Rats
Sport injuries
- Hyperbaric Oxygen Effects on Sports Injuries
- The role of hyperbaric oxygen therapy in sports medicine
- Hyperbaric oxygen therapy for lower-extremity soft-tissue sports injuries
- Hyperbaric Oxygen Therapy in Sports Musculoskeletal Injuries
- Hyperbaric oxygen as an adjuvant for athletes
- [Hyperbaric oxygen treatment of musculoskeletal disorders on the sports medicine. State of the art]
- Hyperbaric oxygen effects on sports injuries
- The Effects of Hyperbaric Oxygen Therapy on Post-Training Recovery in Jiu-Jitsu Athletes
- Improves heart function: Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats.
- Increased ATP production: Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration.
- Increased ATP production: Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury
- Increased ATP production: Stimulation of human damaged sperm motility with hydrogen molecule
- Increased Metabolism: Molecular hydrogen stimulates the gene expression of transcriptional co-activator PGC-1α to enhance fatty acid metabolism
- Post recovery: Is molecular hydrogen beneficial to enhance post-exercise recovery in female athletes
- Prevents cognitive decline: Molecular Hydrogen and its Potential Application in Therapy of Brain Disorders
- Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-Accelerated Mice
- Prevents Muscle fatigue/reduces lactic acid: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes
- Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes
- Selective antioxidant: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
- Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
- Sport Medicine: Molecular hydrogen in sports medicine: new therapeutic perspectives
- Sport related injuries: Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries
- Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes.
Cluster headache * Migraine
- Normobaric and hyperbaric oxygen therapy for migraine and cluster headache – Bennett, MH – 2008
- Hyperbaric oxygen treatment of active cluster headache: a double-blind placebo-controlled cross-over study
- The role of oxygen in cluster headache
- Evidence-based treatments for cluster headache
- Oxygen treatment of cluster headache: A review – Anja S Petersen, Mads CJ Barloese, Rigmor H Jensen, 2014
- Normobaric and hyperbaric oxygen therapy for migraine and cluster headache
High Ranking studies
- Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function
- Effects of hydrogen-rich water on aging periodontal tissues in rats
- Effects of hydrogen-rich water on depressive-like behavior in mice
- Effect of Hydrogen-Rich Water on Oxidative Stress, Liver Function, and Viral Load in Patients with Chronic Hepatitis B
- Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
- Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome
- Hyperbaric hydrogen therapy: a possible treatment for cancer
- Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators
- Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism
- Neuroprotective Effect of Hydrogen-Rich Saline against Neurologic Damage and Apoptosis in Early Brain Injury following Subarachnoid Hemorrhage: Possible Role of the Akt/GSK3β Signaling Pathway
- Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice
- Pilot study of H2 therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial
- The hydrogen highway to reperfusion therapy
Covid 19
- Is there a rationale for hyperbaric oxygen therapy in the patients with Post COVID syndrome? : A critical review
- Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial
- Lower vs Higher Oxygenation Target and Days Alive Without Life Support in COVID-19
- Hyperbare waterstoftherapie verbetert secundair hersenletsel na hoofdtrauma
Glaucoma
Reuma
H² overview studies
- Beneficial biological effects and the underlying mechanisms of molecular hydrogen – comprehensive review of 321 original articles
- Comprehensive Review Study on the Clinical Effects of Hydrogen
- Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications
- Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases
- Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine
- Molecular hydrogen: a therapeutic antioxidant and beyond
- The evolution of molecular hydrogen: A noteworthy potential therapy with clinical significance
Arthritis
- Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study
- Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress
- Molecular Hydrogen: New Antioxidant and Anti-inflammatory Therapy for Rheumatoid Arthritis and Related Diseases
- Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide
- Molecular hydrogen suppresses activated Wnt/β-catenin signaling
- Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study